Placental ECM

InnovaBurn™ is the first placental medical device for complex surgical and burn wounds.


Placental ECM

About InnovaBurn™ Placental ECM

The InnovaBurn™ Placental ECM is a significant and innovative advancement in biologic wound dressings for complex surgical and burn wounds. InnovaBurn™ combines the benefits of the placenta with the reliability, reproducibility, and safety profile of a medical device. It is processed by Triad Life Sciences®’s propriety TriCleanse™ Process that has been demonstrated to disinfect tissues, deactivate viruses, and thoroughly decellularize the ECM.

A Critical Balance

Effective decellularization removes cells and cellular debris while maintaining the structural proteins of the ECM.

Importance of Decellularization or Removal of Cellular Debris

The presence of cells and or cellular debris in biologic wound dressings can cause an inflammatory reaction resulting in a greater M1:M2 ratio macrophage response by the host immune system at the wound site. The greater amount of M1-activated macrophages is necessary to remove the cells and cellular debris before the presence of M2-activated macrophages increases to support a healing response. In contrast, thoroughly decellularized biologic skin scaffolds allow the host to respond directly with a healing response, generally associated with a greater M2:M1 ratio of macrophages and leading to collagen deposition.1

Hematoxylin & Eosin Staining

Hematoxylin and Eosin (H&E) staining is commonly used to stain tissue for histology evaluation.2 H&E stains nuclei blue and extracellular matrix and cytoplasm pink and other tissues shades in between.


The H&E staining shows no residual nuclei in the finished product.

SIS Commercial Membrane

The H&E staining shows clearly stained blue nuclei are distributed evenly throughout the finished product.

HCT/P Commercial Graft

The H&E staining shows blue stained nuclei present in the entirety of the graft with areas of high concentration in the final graft.

InnovaBurn™ Placental ECM, the first placental-derived medical device for complex surgical and burn wounds, provides an exceptionally clean scaffold that aids in the treatment of burn patients. It is also easy to use:

  • No preparation required
  • No specific orientation for placement
  • Conforms and adheres to the wound site

Indications for Use:

  • Partial- and full-thickness wounds
  • Pressure ulcers
  • Venous ulcers
  • Diabetic ulcers
  • Chronic vacular ulcers
  • Tunneled/undermined wounds
  • Draining wounds
  • Surgical wounds (donor sites/grafts, post-Mohs surgery, post-laser surgery, podiatric, wound dehiscence)
  • Trauma wounds (abrasions, lacerations, second-degree burns, and skin tears)
Click here to read the Instructions for Use (IFU) for Innovaburn™ Placental ECM
Size Product Number
5cm x 7cm IMB-0507-01
8cm x 8cm IMB-0808-01
10cm x 10cm IMB-1010-01
10cm x 20cm IMB-1020-01
15cm x 20cm IMB-1520-01

MKT-2021-0024 V01

  1. Keane TJ, Londono R, Turner NJ, Badylak SF. Consequences of ineffective decellularization of biologic scaffolds on the host response. Bio­materials. 2012 Feb;33(6):1771-81
  2. Hinton, J. P., Dvorak, K., Roberts, E., French, W. J., Grubbs, J. C., Cress, A. E., . . . Nagle, R. B. (2019). A Method to Reuse Archived H&E Stained Histology Slides for a Multiplex Protein Biomarker Analysis. Methods Protoc, 2(4).