InnovaMatrix® PD
Placental Extracellular Matrix

InnovaMatrix® PD is the first and only particulate placental ECM medical device cleared by the FDA for wound management.

About InnovaMatrix® PD

About InnovaMatrix® PD

The introduction of InnovaMatrix® PD is an important and innovative advancement in the management of wounds. As a next-generation technology, InnovaMatrix® PD offers the inherent benefits of the placenta3 plus the quality control, reliability, and safety profile of a medical device6. Manufactured with our proprietary TriCleanse Placental Extracellular Matrix (ECM) Process, InnovaMatrix® PD is the next-generation particulate placental device designed for the management of complex surgical wounds, hard-to-heal wounds, and burns.

Indicated For the Management of Wounds Including:*

*See package insert for full list of indications.

Material Selection

While the benefits of placental-derived allografts are well documented1,3, human-derived grafts can be variable due to the unique medical histories and social behaviors of each donor4,5. Knowing this challenge, a porcine source was selected because it can be controlled for age, diet, health, and activity level, thereby reducing the variability of the raw material used to manufacture InnovaMatrix® PD4,5.

The amount of FDA-required material, research, and testing for InnovaMatrix® products contrasts starkly with a simple three-page registration required for HCT/P products.

The InnovaMatrix® Platform material addresses graft variability due to:

  • Genetic variability
  • Environmental/lifestyle factors
  • Diet and activity levels

 The TriCleanse Process balances the need for decellularization while maintaining structural proteins of the ECM that help with healing2,7.

A Critical Balance

Cleaner ECM promotes healing response2,7

Effective decellularization removes cells and cellular debris while maintaining the structural proteins of the ECM that help with healing.

A Critical Balance

Cleaner ECM promotes healing response2,7

The presence of cells and/or cellular debris in biologic wound dressings can cause an inflammatory reaction resulting in a greater M1:M2 ratio macrophage response by the host immune system at the wound site. Thoroughly decellularized biologic skin scaffolds allow the host to respond directly with a healing response, generally associated with a greater M2:M1 ratio of macrophages and leading to collagen deposition7.

Indicated for the Management of Wounds Including:

*See package insert for full list of indications.

  • Partial- and full-thickness wounds
  • Venous ulcers
  • Chronic vascular ulcers
  • Trauma wounds (abrasions, lacerations, and skin tears)
  • Draining wounds
  • Partial-thickness second degree burns
  • Pressure ulcers
  • Diabetic ulcers
  • Tunneled/undermined wounds
  • Surgical wounds (donor sites/ grafts, post-Mohs surgery, post-laser surgery, podiatric, wound dehiscience)

The device is intended for one-time use.

Contraindications
This device is derived from porcine collagen and should not be used on patients with sensitivity or allergy to porcine materials; sensitivity or allergy to collagen; or active or latent infection in or around the application site.
This device is not indicated for use in third degree burns.

Available Sizing

Part # Description Size SQ CM Surface Area
IMP-0100-01 InnovaMatrix® PD 100mg 50 cm2

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InnovaMatrix® PD Documents

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MKT-2022-0104E

  1. Fairbairn, N. G., Randolph, M. A., & Redmond, R. W. (2014). The clinical applications of human amnion in plastic surgery. Journal of Plastic, Reconstructive & Aesthetic Surgery, 67(5), 662-675
  2. Keane, T.J., Londono, R., Turner, N.J., & Badylak, S. F. (2012). Consequences of ineffective decellularization of biologic scaffolds on the host response. Biomaterials, 33(6), 1771-1781. doi:10.1016/j/biomatierlas.2011.10.054
  3. Shaifur Ra, M., Islam, R., Asaduzzama, S.M., & Shahedur R, M. (2015). Properties and Therapeutic Potential of Human Amniotic Membrane. Asian Journal of Dermatology, 7(1), 1-12. doi: 10.3923/ajd.2015.1.12
  4. Cardinal, L.J. (2015). Central tendency and variability in biological systems. J Community Hosp Intern Med Perspect, 5(3), 27930. doi:10.3402/jchimp.v5.27930
  5. O’Huallachain, M., Karczewski, K. J., Weissman, S.M., Urban, A. E., & Snyder, M. P. (2012). Extensive genetic variation in somatic human tissues. Proc Natl Acad Sci U S A, 109(44), 18018-18023. doi: 10.1073/pnas.1213736109
  6. Sicari, B.M., Dziki, J.L., Siu, B.F., Medberry, C.J., Dearth, C.L., & Badylak, S.F. (2014). The promotion of a constructive macrophage phenotype by solubilized extracellular matrix. Biomaterials, 35(30), 8605-8612. doi:10.1016/j.biomaterials.2014.06.060